Paper Publications
-
[1] Xuebo Yao , Yan Zhang , Xiaying Hong , Yanyi Xing and Zhigang Xu. Esrp1 and Esrp2 regulate the stability of tmc1/2a mRNAs in zebrafish Sensory Hair Cells. Journal of Neuroscience, 45, e0837242025, 2025.
-
[2] Shaoxuan Wu , Lin Lin , Qiaoyu Hu , Xuebo Yao , Hongyang Wang , Shang Liu , Qingling Liu , Yuehui Xi , Yuzhe Lin , Jianqiao Gong , Ruixing Hu , Wei Zhan , Yi Luo , Guang He , Zhijun Liu , Wei Xiong , Qiuju Wang , Zhigang Xu , Fang Bai and Qing Lu. Mechano-electrical transduction components TMC1-CIB2 undergo a Ca2+-induced conformational change linked to hearing loss. Developmental Cell, 60, 1586-1600, 2025.
-
[3] Keji Yan , Haoqing Zhang , Chengli Qu , Yuehui Xi , Ze-Guang Han and Zhigang Xu. BAIAP2L1 and BAIAP2L2 differently regulate hair cell stereocilia morphology. FASEB J, 38, e23860, 2024.
-
[4] Nana Li , Shuang Liu , Dange Zhao , Haibo Du , Yuehui Xi , Xiaoxi Wei , Qingling Liu , Ulrich Müller , Qing Lu , Wei Xiong and Zhigang Xu. Disruption of Cdh23 exon 68 splicing leads to progressive hearing loss in mice by affecting tip-link stability. Proc Natl Acad Sci U S A, 121, e2309656121, 2024.
-
[5] Ying Guan , Hai-Bo Du , Zhao Yang , Yu-Zhu Wang , Rui Ren , Wen-Wen Liu , Chao Zhang , Jia-Hai Zhang , Wen-Tao An , Na-Na Li , Xiao-Xue Zeng , Jie Li , Yi-Xiao Sun , Yan-Fei Wang , Fan Yang , Jun Yang , Wei Xiong , Xiao Yu , Ren-Jie Chai , Xiao-Ming Tu , Jin-Peng Sun and Zhi-Gang Xu. Deafness-associated ADGRV1 mutation impairs USH2A stability through improper phosphorylation of WHRN and WDSUB1 recruitment. Advanced Science, 10, e2205993, 2023.
-
[6] Xiaoying Wang , Shuang Liu , Qi Cheng , Chengli Qu , Rui Ren , Haibo Du , Nana Li , Keji Yan , Yanfei Wang , Wei Xiong and Zhigang Xu. CIB2 and CIB3 regulate stereocilia maintenance and mechanoelectrical transduction in mouse vestibular hair cells. Journal of Neuroscience, 43, 3219-3231, 2023.
-
[7] Rui Ren , Haiyue Xing , Xiaoying Wang , Haibo Du , Yanfei Wang and Zhigang Xu. Loss of TMCC2 activates endoplasm reticulum stress and causes auditory hair cell death. Human Molecular Genetics, 32, 1622-1633, 2023.
-
[8] Huang Wang , Haibo Du , Rui Ren , Tingting Du , Lin Lin , Zhe Feng , Dange Zhao , Xiaoxi Wei , Xiaoyan Zhai , Hongyang Wang , Tingting Dong , Jin-Peng Sun , Hao Wu , Zhigang Xu and Qing Lu. Temporal and spatial assembly of inner ear hair cell ankle link condensate through phase separation. Nature Communications, 14, 1657, 2023.
-
[9] Xiaoyan Zhai , Haibo Du , Yuxin Shen , Xiujuan Zhang , Zhengjun Chen , Yanfei Wang and Zhigang Xu. FCHSD2 is required for stereocilia maintenance in mouse cochlear hair cells. Journal of Cell Science, 135, jcs259912, 2022.
-
[10] Haibo Du , Linzhi Zou , Rui Ren , Nana Li , Jie Li , Yanfei Wang , Jinpeng Sun , Jun Yang , Wei Xiong and Zhigang Xu. Lack of PDZD7 long isoform disrupts ankle-link complex and causes hearing loss in mice. FASEB Journal, 34, 1136, 2020.
-
[11] Xiao-Ning Cheng , Ming Shao , Ji-Tong Li , Yan-Fei Wang , Jing Qi , Zhi-Gang Xu and De-Li Shi. Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish. Nature Communications, 8, 1353, 2017.
-
[12] Qiao-Xia Hu , Jun-Hong Dong , Hai-Bo Du , Dao-Lai Zhang , Hong-Ze Ren , Ming-Liang Ma , Yuan Cai , Tong-Chao Zhao , Xiao-Lei Yin , Xiao Yu , Tian Xue , Zhi-Gang Xu and Jin-Peng Sun. Constitutive Gαi coupling activity of very large G protein-coupled receptor 1 (VLGR1) and its regulation by PDZD7 protein. Journal of Biological Chemistry, 289, 24215-24225, 2014.